It formed part of the Government army sent to defeat the Jacobite rising of 1745, participating in the Battle of Falkirk in January 1746 and in the Battle of Culloden in April 1746. The regiment was deployed to the West Indies in late 1739 but returned in December 1740. A contingent from the regiment took part in the Siege of Namur in August 1695 during the Nine Years' War. As such it then fought at the Battle of the Boyne in July 1690, at the Battle of Aughrim in July 1691and at the Siege of Limerick in August 1691. The regiment served successfully, most notably at the Battle of Newtownbutler in July 1689, and it gained a place on the English establishment in 1690 as a regular infantry regiment.
The regiment was raised as local militia at Enniskillen by Colonel Zachariah Tiffin as Zacharaiah Tiffin's Regiment of Foot in June 1689, to fight against James II in the Williamite War in Ireland.
